Thermo Fisher Scientific Granzyme B Monoclonal Antibody (GB12), PE
인간 Granzyme B를 특이적으로 인식하는 마우스 단클론 항체로, PE 형광표지되어 세포분석(Flow Cytometry)에 적합합니다. IHC 및 다양한 종에 반응하며, 고순도 정제 및 안정적 저장용액으로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Publications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Not specified
- Publications: View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
- Publications: View 51 publications
Miscellaneous PubMed (Misc)
- Tested Dilution: Not specified
- Publications: View 14 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Dog, Human, Mouse, Rhesus monkey |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GB12 |
| Immunogen | Human Granzyme B |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS with 10% sucrose, 4 mg/mL BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10372671 |
Additional Formats
Product Specific Information
- Literature indicates this antibody recognizes Granzyme B1.
- Each lot is tested by flow cytometry using peripheral blood leukocytes.
- Recommended usage: 5 µL antibody per 1 × 10⁶ cells.
- For R-PE conjugates: excitation 488 nm / emission 575 nm.
- Matching isotype control available: Mouse IgG1 R-PE (#MG104).
Target Information
Granzyme B is a serine protease found in cytotoxic T cells and NK cells. It plays a critical role in inducing apoptosis in target cells by activating caspase-3 and initiating the caspase cascade. Granzyme B can also trigger mitochondrial apoptosis via Bid cleavage. It is stored in lytic granules of CTLs and NK cells and is essential for immune-mediated cytotoxicity. In humans, fewer granzyme types have been cloned compared to mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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