Thermo Fisher Scientific Granzyme B Monoclonal Antibody (GB12), PE

Applications and Publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Not specified
• Publications: View 1 publication

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent
• Publications: View 51 publications

Miscellaneous PubMed (Misc)

• Tested Dilution: Not specified
• Publications: View 14 publications

Product Specifications

Additional Formats

• APC Conjugate (MHGB05)
• Request custom conjugation

Product Specific Information

• Literature indicates this antibody recognizes Granzyme B1.
• Each lot is tested by flow cytometry using peripheral blood leukocytes.
• Recommended usage: 5 µL antibody per 1 × 10⁶ cells.
• For R-PE conjugates: excitation 488 nm / emission 575 nm.
• Matching isotype control available: Mouse IgG1 R-PE (#MG104).

Target Information

Granzyme B is a serine protease found in cytotoxic T cells and NK cells. It plays a critical role in inducing apoptosis in target cells by activating caspase-3 and initiating the caspase cascade. Granzyme B can also trigger mitochondrial apoptosis via Bid cleavage. It is stored in lytic granules of CTLs and NK cells and is essential for immune-mediated cytotoxicity. In humans, fewer granzyme types have been cloned compared to mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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