Thermo Fisher Scientific COPS7A Polyclonal Antibody
Thermo Fisher Scientific의 COPS7A Polyclonal Antibody는 인간 COPS7A 단백질을 인식하는 토끼 유래 IgG 항체입니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며, 안정한 장기 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COPS7A. Recombinant protein control fragment (Product #RP-100950). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640065 |
Product Specific Information
Immunogen sequence:
KVTGQNQEQF LLLAKSAKGA ALATLIHQVL EAPGVYVFGE LLDMPNVREL AESDFASTFR LLTVFAYGTY ADYLAEARNL PPLTEAQKNK LRHLSVVTLA AKVKCIPYAV LLEALALRNV RQLEDLVIEA VYADVLRGSL D
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
The COP9 signalosome (CSN) complex is involved in various developmental and cellular processes. It consists of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b), and CSN8 (COP8).
The CSN complex regulates the ubiquitin conjugation pathway by mediating deneddylation of SCF-type E3 ligase complexes, reducing their ubiquitin ligase activity. It also participates in phosphorylation processes involving p53, c-Jun, IκB-alpha, and IRF-8. CSN7 is phosphorylated by CK2 and consists of two subunits, α and β.
CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region and a coiled-coil region, predicted to interact with CSN2–CSN8 and GPS1, while CSN7b contains only a PCI region and interacts with INT6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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