Thermo Fisher Scientific TREX1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease required for checkpoint signaling after DNA damage. It is ubiquitously expressed and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. Trex1 recruits ATR, a checkpoint kinase, to sites of DNA damage and replication stress, and is essential for ATR expression.
This gene utilizes two open reading frames:

• The upstream ORF encodes proteins that interact with ATR and localize to intranuclear foci induced by DNA damage.
• The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity and may be a subunit of human DNA polymerase III.

Multiple transcript variants encoding different isoforms have been identified. Mutations in this gene are associated with Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.