Thermo Fisher Scientific TREX1 Polyclonal Antibody
TREX1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western Blot, IHC, ELISA, IP 등 다양한 응용에 적합하며, Affinity chromatography로 정제되었습니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
- 카탈로그번호
- TREX1-101AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 220–245 on human TREX1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease required for checkpoint signaling after DNA damage. It is ubiquitously expressed and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. Trex1 recruits ATR, a checkpoint kinase, to sites of DNA damage and replication stress, and is essential for ATR expression.
This gene utilizes two open reading frames:
- The upstream ORF encodes proteins that interact with ATR and localize to intranuclear foci induced by DNA damage.
- The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity and may be a subunit of human DNA polymerase III.
Multiple transcript variants encoding different isoforms have been identified. Mutations in this gene are associated with Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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