Thermo Fisher Scientific ORC3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human ORC3L protein. Validated for WB, IHC(P), and ICC/IF applications. Recommended for use with H1299 cells. Predicted cross-reactivity with rat and bovine. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 48–315 of Human ORC3L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.52 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547949 |
Product Specific Information
- Recommended positive control: H1299 cells
- Predicted reactivity: Rat (82%), Bovine (88%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Histone deacetylase 2 (HDAC2), also known as transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely involved in regulating chromatin structure during transcription. It has been implicated in association with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly conserved from yeast to human.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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