Thermo Fisher Scientific SMN1 Polyclonal Antibody
SMN1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot 및 IHC에 사용 가능. 인간 샘플에 반응하며, 합성 펩타이드(aa 150-200)로 면역화. 동결건조 형태로 제공되며, 4°C 단기 보관 또는 -20°C 장기 보관 권장. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 150–200 of human SMN1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SMN1.
Target Information
The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13.
This region contains multiple genes and repetitive elements, making it prone to rearrangements and deletions.
The telomeric and centromeric copies encode the same survival motor neuron protein, which plays a catalytic role in assembling small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome.
Mutations in the SMN1 gene are known to cause spinal muscular atrophy (SMA) types 1 and 2.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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