Thermo Fisher Scientific GCH1 Monoclonal Antibody (OTI7B8)
GCH1 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI7B8). Western blot과 IHC(P)에서 검증됨. 인체 시료에 반응하며, 1 mg/mL 농도의 액상형 항체로 PBS, BSA, glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B8 |
| Immunogen | Full length human recombinant protein of GCH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724351 |
Target Information
The GCH1 gene encodes a member of the GTP cyclohydrolase family. This protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases and nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; not all variants produce a functional enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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