Thermo Fisher Scientific TAB182 Polyclonal Antibody
Human TAB182 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:500~1:1,000 희석 비율로 검증됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TAB182 Polyclonal Antibody
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TAB182. Recombinant protein control fragment (Product #RP-97362). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648175 |
Product Specific Information
- Immunogen sequence:
DWTPDLGLRN MAPGAVCSPG ESKELGVGQM DWGNNLGLRD LEVTCDPDSG GSQGLRGCGV GQMDWTQDLA PQNVELFGAP SEARE - Highest antigen sequence identity:
- Mouse: 75%
- Rat: 76%
Target Information
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen searching for tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 results in inhibition of TRF1 binding and induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain, suggesting that TAB182 may act as a scaffold mediating higher-order protein complex formation at telomeres. TAB182 also localizes to the cytoplasmic cortical actin network, implying a role in cytoplasmic processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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