Thermo Fisher Scientific TAB182 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TAB182. Recombinant protein control fragment (Product #RP-97362). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TAB182,uniProtId:Q9C0C2-1,ncbiNodeId:9606,antigenRange:1280-1364,antigenLength:1729,antigenImageFileName:PA5-58171_TAB182_Q9C0C2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58171_TAB182_Q9C0C2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648175

Product Specific Information

Immunogen sequence: DWTPDLGLRN MAPGAVCSPG ESKELGVGQM DWGNNLGLRD LEVTCDPDSG GSQGLRGCGV GQMDWTQDLA PQNVELFGAP SEARE

Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 76%.

Target Information

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.