Thermo Fisher Scientific Human IL-12 p80 Recombinant Protein, PeproTech

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

-

In vitro Assay (IV)

-

View 11 publications 11 publications

Product Specifications

Species

Human

Published species

Human

Expression System

Insect cells

Amino acid sequence

p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS

Molecular weight

80 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Product Specific Information

200-12P80H-1MG will be provided as 10 x 100 µg (200-12P80H-100UG).

200-12P80H-250UG will be provided as multiple 50 µg (200-12P80H-50UG) and 100 µg (200-12P80H-100UG) vials.

200-12P80H-500UG will be provided as 5 x 100 µg (200-12P80H-100UG).

Recombinant Human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.