Thermo Fisher Scientific CCDC8 Polyclonal Antibody
Thermo Fisher Scientific의 CCDC8 Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 다양한 면역학적 분석(WB, IHC, ICC, ELISA)에 사용 가능합니다. 단백질 A 정제된 고품질 rabbit IgG 항체로, 안정적인 액상 형태로 제공되어 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CCDC8, amino acids 165–270 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB, and TFEC.
The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer.
TFEC forms heterodimers with TEF3 and inhibits TFE3-dependent transcription activation.
TEF3 interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing roles in cell growth, proliferation, and differentiation.
TFE3 also activates hepatic IRS-2 gene and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1), participating in insulin signaling and potentially serving as a therapeutic target for diabetes.
This gene is involved in chromosomal translocations resulting in fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3, and ASPL-TFE3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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