Thermo Fisher Scientific NMT2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 79%

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, heat shock and stress response, antigen presentation, cell surface receptor modulation, ion channel regulation, cell cycle control, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most cytosolic and nuclear proteins in eukaryotic cells, while others are degraded via the vacuolar pathway, including endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (~31) molecular complex (~2.5 MDa) consisting of a 20S proteolytic core and one or two 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins, unfolding and translocating them into the 20S lumen.
An enzymatic cascade attaches multiple ubiquitin molecules to lysine residues of target proteins for degradation. Defects in this pathway are associated with genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.