Thermo Fisher Scientific CtIP Polyclonal Antibody
CtIP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 ChIP assay에 최적화됨. 인간에 반응하며 BRCA1 상호작용 연구에 유용. 항원 친화 크로마토그래피로 정제된 액상 항체로, 고농도(1 mg/mL)로 제공.
- 카탈로그번호
- PA521983
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CtIP Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:1,000–1:10,000
- ChIP assay (ChIP): 2.5 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 452–777 of CtIP (Uniprot ID# Q99708) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152914 |
Product Specific Information
- Recommended positive controls: A431, H1299, HeLa, HepG2, Raji
- Predicted reactivity: Rhesus Monkey (95%)
- Store product as a concentrated solution; centrifuge briefly prior to opening the vial.
Target Information
CtIP is a 125 kD protein originally identified as interacting with the transcription repressor CtBP via the PLDLS motif (CtBP-Interacting Protein), suggesting a role in transcription regulation.
CtIP also interacts with BRCA1 through its C-terminal BRCT domains, indicating a potential tumor suppressor function.
This CtIP–BRCA1 interaction can be disrupted by DNA-damaging agents such as UV or gamma irradiation.
Li et al. (Nature 406, 210–215, 2000) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745; mutation of these sites prevents BRCA1 dissociation from CtIP, maintaining repression of BRCA1-dependent GADD45 induction upon ionizing radiation.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-21983_CtIP_Q99708-1_Rabbit.svg, PA5-21983_CtIP_Q99708-1_Rabbit_PDP.jpeg)
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