Thermo Fisher Scientific RGS14 Polyclonal Antibody
RGS14 단백질을 인식하는 Goat Polyclonal Antibody로 Western blot에 적합. 인간 시료 반응성 확인됨. 고순도 액상 형태로 제공되며 TBS 버퍼에 BSA 포함. 세포 신호전달 및 신경 성장 관련 연구용으로 적합.
- 카탈로그번호
- PA518278
- 판매단위
- pk
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Applications
- Western Blot (WB): 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (IGGSLNSTTDSAL) corresponding to the C-terminus amino acids of RGS14 (aa 554–566) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10979893 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
RGS14 is a member of the regulator of G-protein signaling family which contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain.
RGS14 attenuates G-protein signaling by binding to activated, GTP-bound G alpha subunits via its GoLoco domain, functioning as a GTPase activating protein (GAP).
This accelerates GTP hydrolysis, allowing G alpha subunits to reassociate with G beta/gamma heterodimers, forming inactive G-protein complexes and terminating the signal.
RGS14 also acts as a positive modulator of microtubule polymerization and spindle organization through a G(i)-alpha-dependent mechanism, playing roles in cell division, NGF-mediated neurite outgrowth, and stress resistance.
It may be involved in visual memory processing and hippocampal-based learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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