Thermo Fisher Scientific MICA Monoclonal Antibody (MICA/4442)
인간, 마우스, 랫트에 반응하는 MICA 단일클론 항체로 Western blot과 IHC 등 다양한 응용에 적합. 비결합형 액상 형태로 제공되며 고순도 Protein A/G 정제. 4°C에서 보관, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MICA/4442 |
| Immunogen | Recombinant fragment (around aa1–200) of human MICA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
Target Information
Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. A related family, termed the MHC class I chain-related (MIC) proteins, are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity.
MICA, a member of the MIC family, is widely expressed on many tumors, and the MICA/NKG2D interaction is thought to stimulate anti-tumor reactivity by T lymphocytes. Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system. This suggests that MIC protein expression may be one component of the immune system’s anti-tumor activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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