Thermo Fisher Scientific DDB2 Polyclonal Antibody
DDB2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합. 인간 및 마우스 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태, -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific DDB2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DDB2 (Accession Q92466), corresponding to amino acid residues T338–D388 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899364 |
Product Specific Information
Antibody detects endogenous levels of total DDB2.
Target Information
Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, designated DDB1 and DDB2. The DDB heterodimer participates in repairing DNA damaged by ultraviolet light. Also known as UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF), and hepatitis B virus X-associated protein 1 (XAP-1), DDB binds to damaged cyclobutane pyrimidine dimers (CPDs).
Mutations in the DDB2 gene cause xeroderma pigmentosum group E, an autosomal recessive disease characterized by defective nucleotide excision DNA repair, hypersensitivity to sunlight, frequent skin cancer, and neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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