Thermo Fisher Scientific PCP4 Polyclonal Antibody
PCP4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 인간 및 생쥐 시료 반응성이 있으며, 항원 친화 크로마토그래피로 정제된 고품질 항체입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific PCP4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:300 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human Purkinje cell protein 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635641 |
Product Specific Information
The antibody detects endogenous levels of total PCP4 protein.
Target Information
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas and neurodegenerative disorders such as Alzheimer’s disease and Huntington’s disease. Overexpression of PCP-4 may contribute to cerebellar hypoplasia, a key feature of Down syndrome.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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