Thermo Fisher Scientific USP51 Polyclonal Antibody
USP51 단백질을 검출하기 위한 Rabbit Polyclonal Antibody로 Western blot에 적합. 인간, 생쥐, 원숭이, 랫트에서 반응. 액상 형태로 1 mg/mL 농도, 친화 크로마토그래피로 정제. -20°C에 보관하며 연구용으로만 사용.
- 카탈로그번호
- PA5104203
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human USP51 (Accession Q70EK9), corresponding to amino acid residues T317–N367 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853531 |
Product Specific Information
Antibody detects endogenous levels of total USP51.
Target Information
USP51 (Ubiquitin Specific Peptidase 51) is a protein-coding gene. It participates in the Ubiquitin-Proteasome Dependent Proteolysis pathway. Gene Ontology (GO) annotations include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity.
Specifically deubiquitinates Lys-14 (H2AK13Ub) and Lys-16 (H2AK15Ub) of histone H2A, regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1.
Also exhibits activity for Lys-27 or Lys-63-linked di-ubiquitin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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