Thermo Fisher Scientific C5AR1 Polyclonal Antibody
Rabbit polyclonal antibody against human C5AR1 (CD88) for Western blot analysis. Detects endogenous C5AR1 protein. Affinity purified, supplied as liquid in PBS with glycerol. Suitable for research use only.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human C5AR1 (Accession P21730), corresponding to amino acid residues L311–V350 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818820 |
Product Specific Information
Antibody detects endogenous levels of total C5AR1.
Target Information
CD88 (C5aR1) is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma and is expressed in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 functions as the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, and superoxide anion production.
It is also a component of the classical pathway of the complement cascade and may be involved in tissue injury associated with ischemia or sepsis, as well as the membrane attack complex.
Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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