Thermo Fisher Scientific GATM Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423-amino-acid protein belonging to the amidinotransferase family. Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and forms a homodimer, with monomeric subunits favored in equilibrium.
AGAT localizes to mitochondrial inner membranes, peripheral membranes, and cytoplasm. It is expressed in placenta, fetal tissues, brain, heart, liver, lung, salivary gland, and skeletal muscle, with high expression in kidney.
AGAT is elevated in myocardium during heart failure and decreased in IUGR-associated placenta. It catalyzes the biosynthesis of guanidinoacetate, the precursor of creatine, essential for muscle energy metabolism.
Defects in AGAT are linked to arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay, mental retardation, speech disturbance, and creatine depletion in the brain.
AGAT may play roles in embryonic and CNS development and heart failure response via local creatine synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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