Thermo Fisher Scientific GATM Polyclonal Antibody
Thermo Fisher Scientific의 GATM Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 고순도 항체로 Western blot, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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- PA587228
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human GATM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803977 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423-amino-acid protein belonging to the amidinotransferase family. Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and forms a homodimer, with monomeric subunits favored in equilibrium.
AGAT localizes to mitochondrial inner membranes, peripheral membranes, and cytoplasm. It is expressed in placenta, fetal tissues, brain, heart, liver, lung, salivary gland, and skeletal muscle, with high expression in kidney.
AGAT is elevated in myocardium during heart failure and decreased in IUGR-associated placenta. It catalyzes the biosynthesis of guanidinoacetate, the precursor of creatine, essential for muscle energy metabolism.
Defects in AGAT are linked to arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay, mental retardation, speech disturbance, and creatine depletion in the brain.
AGAT may play roles in embryonic and CNS development and heart failure response via local creatine synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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