Thermo Fisher Scientific Human EGFR (ErbB1) [T790M], GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent
Publications: -

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
• For larger sizes, aliquoting can reduce freeze/thaw cycles; do not prepare aliquots below 20 µL.
• Never store kinase diluted.
• When properly stored at -80°C, guaranteed for 6 months from date of purchase.
• Protein Form: Cytoplasmic

Target Information

EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression is associated with numerous cancers, making EGFR a key target for biological and small molecule therapeutics.
The EGFR gene is located on chromosome 7 and belongs to the HER/ErbB family, which includes ERbB2, ERbB3, and ERbB4. EGFR is a transmembrane receptor; ligand binding (e.g., EGF, TGF-α) induces dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.