Thermo Fisher Scientific CHK2 Monoclonal Antibody (1C12B8)
CHK2 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC에 사용 가능. 인간 및 비인간 영장류 반응성. 단백질 A 정제, PBS/BSA/glycerol 저장. DNA 손상 반응 및 종양 억제 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C12B8 |
| Immunogen | Purified recombinant fragment of human CHK2 (aa481–531) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985877 |
Product Specific Information
CHK2 has a predicted molecular weight of 61 kDa, and by Western blot, MA5-15416 detects CHK2 between 60–65 kDa.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a key component of the DNA damage checkpoint pathway. Mutations in CHK2 have been linked to various cancers. Upon DNA damage, CHK2 phosphorylates multiple modulators of cell cycle control, including tumor suppressor proteins such as BRCA1. This phosphorylation enables BRCA1 to restore cell survival after DNA damage. CHK2 functions as a putative tumor suppressor, and mutations in the CHK2 gene are associated with Li-Fraumeni syndrome, sarcomas, breast cancer, and brain tumors.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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