Thermo Fisher Scientific CPSF1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: 293T, NIH/3T3, Mouse liver
• Immunogen sequence:
  LYRDLSGMFT TESRLGGARD ELGGRSGPEA EGLGSETSPT VDDEEEMLYG DSGSLFSPSK EEARRSSQPP ADRDPAPFRA EPTHWCLLVR ENGTMEIYQL PDWRLVFLVK NFPVGQRVLV DSSFGQPTTQ GEARREEATR QGELPLVKEV LLVALGSRQS RPYLLVHVDQ ELLIYEAFPH DSQLGQGNLK VRFKKVPHNI NFREKKPKPS KKKAEGGGAE EGAGARGRVA RFRYFEDIYG YSGVFICGPS P

Target Information

Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1.
Midline-1 belongs to the TRIM/RBCC family and contains:

• Two B box-type zinc fingers
• One B30.2/SPRY domain
• One COS domain
• One fibronectin type-III domain
• One RING-type zinc finger

Midline-1 exhibits E3 ubiquitin ligase activity, targeting the catalytic subunit of protein phosphatase 2 for degradation. It forms homo- or heterodimers with Midline-2 and interacts with IGBP1 (Lymphocyte signaling protein A4).
Defects in MID1 cause Opitz syndrome type I (OS-I), an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects, cleft lip/palate, imperforate anus, developmental delay, and congenital heart defects.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.