Thermo Fisher Scientific NAE1 Monoclonal Antibody (4E8-H3)
Thermo Fisher Scientific의 NAE1 Monoclonal Antibody (4E8-H3)는 인간 NAE1 단백질을 타겟으로 하는 Mouse IgG2a 항체입니다. Western blot 및 ELISA에 적합하며, 액상 형태로 제공됩니다. 연구용으로만 사용되며 Alzheimer’s disease 관련 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E8-H3 |
| Immunogen | NAE1 (AAH00480, 1–534 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic), Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK YLAQWYSETN GRIPKTYKEK EDFRDLIRQG ILKNENGAPE DEENFEEAIK NVNTALNTTQ IPSSIEDIFN DDRCINITKQ TPSFWILARA LKEFVAKEGQ GNLPVRGTIP DMIADSGKYI KLQNVYREKA KKDAAAVGNH VAKLLQSIGQ APESISEKEL KLLCSNSAFL RVVRCRSLAE EYGLDTINKD EIISSMDNPD NEIVLYLMLR AVDRFHKQQG RYPGVSNYQV EEDIGKLKSC LTGFLQEYGL SVMVKDDYVH EFCRYGAAEP HTIAAFLGGA AAQEVIKIIT KQFVIFNNTY IYSGMSQTSA TFQL
Target Information
The protein encoded by this gene binds to the beta-amyloid precursor protein, which is a cell surface protein with signal-transducing properties and may play a role in Alzheimer’s disease pathogenesis. It forms a heterodimer with UBE1C and activates NEDD8, a ubiquitin-like protein, necessary for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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