Thermo Fisher Scientific TRPC6 (extracellular) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.

Target Information

Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium.
Defects in the Trpc6 gene are associated with focal segmental glomerulosclerosis 2 (FSGS2).
Trpc6 is part of the mammalian transient receptor potential (TRP) superfamily, specifically the “canonical TRP” (TRPC) family. The seven members of this family share activation through PLC-coupled receptors and function as receptor-regulated cation channels in various cell types.
Members of the TRPC3/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a PLC-coupled receptor activation mechanism. When expressed in transfected cells, Trpc6 acts as a non-selective, store-independent receptor-activated cation channel.
Trpc6 is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. Evidence indicates that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
Diseases associated with TRPC6 include Focal Segmental Glomerulosclerosis (FSGS2).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.