Thermo Fisher Scientific SETX Polyclonal Antibody
Human SETX 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC 및 ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다. RNA/DNA helicase 관련 연구에 활용 가능합니다.
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Thermo Fisher Scientific SETX Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SETX (Product #RP-92909) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2647169 |
Product Specific Information
Immunogen sequence:
CCWCTPGGAS TIDFLKRYAS NTPSGEFQTA DEDLCYCLEC VAEYHKARDE LPFLHEVLWE LETLRLINHF EKSMKAEIGD DDELYIVDNN GEMPLFDITG QDFEN
Highest antigen sequence identity to orthologs:
- Mouse: 85%
- Rat: 86%
Target Information
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity.
Plays a role in transcription regulation by modulating RNA Polymerase II binding to chromatin and interacting with transcription-related proteins.
Contributes to mRNA splicing efficiency and splice site selection.
Required for resolution of R-loop RNA-DNA hybrid formation and efficient RNA polymerase II transcription termination.
Participates in circadian rhythm regulation, DNA damage response, germ cell development, and telomeric stability.
Also involved in neurite outgrowth and inhibition of retinoic acid-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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