Thermo Fisher Scientific NPAS2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NPAS2.

Target Information

Members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family are transcription factors containing a bHLH DNA-binding domain located amino-terminal to a PAS domain.
Neuronal PAS domain protein 2 (NPAS2, also designated PAS4/MOP4) is a member of the bHLH-PAS family and the PAS superfamily.
NPAS2, mapped to chromosome 2p11.2–2q13, is primarily expressed in neurons during the first week of postnatal development.
Its expression pattern matches the development of learning and memory, particularly in the frontal association and limbic forebrain pathways.
NPAS2 may play a regulatory role in long-term memory development and complex sensory information processing.
NPAS2 and MOP3 form a transcriptionally active heterodimer that binds to a CACGTGA-containing DNA element, driving transcription from a linked luciferase reporter gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.