Thermo Fisher Scientific RNF216 Polyclonal Antibody

Applications

• Western Blot (WB): Assay-dependent

Product Specifications

Product Specific Information

A suggested positive control for this product is testis or peripheral blood leukocytes.

Target Information

Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms control TLR signal transduction, including inhibition by molecules such as ST2 and SIGIRR.
Another regulatory mechanism involves ubiquitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A, a RING finger protein, binds to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing their ubiquitinization. Overexpression of TRIAD3A promotes degradation of TLR4 and TLR9, reducing signal-specific activation. Conversely, depletion of TRIAD3A enhances TLR activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.