Thermo Fisher Scientific RNF216 Polyclonal Antibody
RNF216 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 토끼에서 유래한 IgG 형식입니다. Western blot 분석에 적합하며, TRIAD3A의 N-말단 근처 펩타이드를 면역원으로 사용했습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to 15 residues near the N-terminus of mouse TRIAD3A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1088061 |
Product Specific Information
A suggested positive control for this product is testis or peripheral blood leukocytes.
Target Information
Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms control TLR signal transduction, including inhibition by molecules such as ST2 and SIGIRR.
Another regulatory mechanism involves ubiquitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A, a RING finger protein, binds to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing their ubiquitinization. Overexpression of TRIAD3A promotes degradation of TLR4 and TLR9, reducing signal-specific activation. Conversely, depletion of TRIAD3A enhances TLR activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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