Thermo Fisher Scientific VANGL1 Polyclonal Antibody
Human VANGL1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 적용 가능하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보존되어 장기 저장 시 -20°C에서 안정적.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human VANGL1. Recombinant protein control fragment (Product #RP-91180). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649388 |
Product Specific Information
Immunogen sequence:
DTESTYSGYS YYSSHSKKSH RQGERTRERH KSPRNKDGRG SEKSVTIQPP TGEPLLGNDS TRTEEVQDDN WGETTTAITG TSEHSISQED IARISKDMED SVGLDCKRY
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif.
Studies show that the expression of the protein is significantly up-regulated in gastric and pancreatic cancer cell lines (MKN28, MKN74, BxPC-3, PSN-1, Hs766T).
The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa and as a diagnostic marker for hepatocellular carcinoma.
It is also implicated in neural tube defects (NTD).
Human Vang-like 1 gene maps to chromosome 1p11–p13.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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