Thermo Fisher Scientific bFGF Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

FGF2 (also known as FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor family and interacts with high-affinity transmembrane receptors to regulate cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is mainly cytosolic and acts through cell surface receptors, while the 22, 22.5, 24, and 34 kDa isoforms are nuclear and may signal independently of transmembrane receptor pathways.
In humans, the gene is located on the q arm of chromosome 4. FGF2 is implicated in processes such as limb and nervous system development, wound healing, and tumor growth.
The mRNA for FGF2 contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG initiation codons, resulting in five isoforms with distinct properties. The CUG-initiated isoforms are nuclear and responsible for intracrine effects, whereas the AUG-initiated form is cytosolic and mediates paracrine and autocrine effects.
Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.