Thermo Fisher Scientific Phospho-JAK1 (Tyr1022, Tyr1023) Polyclonal Antibody
JAK1 단백질의 Tyr1022 및 Tyr1023 인산화 상태를 검출하는 폴리클로날 항체. Western blot 및 Immunocytochemistry에 적합. Human과 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 18 publications |
| Immunocytochemistry (ICC/IF) | 1:250 | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Non-human primate, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human JAK1 protein that contains tyrosines 1022 and 1023. The sequence is conserved in mouse and pig. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533648 |
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli such as interferons and cytokines induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to play a role in activation of catalytic events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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