Thermo Fisher Scientific PSMB7 Monoclonal Antibody (OTI1E1)
PSMB7 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, WB 및 IHC(P)에서 사용 가능. 인간, 마우스, 영장류 반응성. 액상 형태로 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 58–277 of PSMB7 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723529 |
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure composed of four rings of 28 non-identical subunits. Two rings consist of seven alpha subunits and two rings of seven beta subunits. Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
The immunoproteasome plays a crucial role in processing class I MHC peptides. The PSMB7 gene encodes a member of the proteasome B-type (T1B) family, a 20S core beta subunit. Its expression is downregulated by gamma interferon, and proteolytic processing is required to generate the mature subunit. This subunit is replaced by catalytic subunit 2i (proteasome beta 10 subunit) in the immunoproteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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