Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (OTI4F8)
GEMIN8 단백질을 인식하는 Thermo Fisher Scientific의 OTI4F8 단일클론 항체로, WB 및 IHC(P) 분석에 적합. 인간 시료에 반응하며 액상 형태로 제공. 고순도 친화 크로마토그래피 정제, 안정적 PBS 기반 버퍼 포함.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F8 |
| Immunogen | Full length human recombinant GEMIN8 protein produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3), with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724361 |
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome. It is involved in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA to create the core snRNP. In the cytosol, Sm proteins are held in an inactive 6S pICln-Sm complex by chaperone CLNS1A. The SMN complex dissociates CLNS1A and transfers Sm proteins to form SMN-Sm complexes, initiating core snRNP assembly and nuclear transport.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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