Thermo Fisher Scientific MMP2 Monoclonal Antibody (OTI4B11), TrueMAB
인간 MMP2 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합. 무보존제, 동결건조 형태로 제공되며 재구성 후 약 1 mg/mL 농도. 조직 재형성 및 MMP 관련 연구용으로 최적화된 TrueMAB 항체.
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Thermo Fisher Scientific MMP2 Monoclonal Antibody (OTI4B11), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 228–507 of human MMP2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade connective tissue components. They share a conserved activation mechanism and metal-binding active site, and are regulated by tissue inhibitors of metalloproteinases (TIMPs).
MMP2, a 631-amino-acid proenzyme, is activated by cleavage of the first 80 amino acids and includes propeptide, catalytic, and hemopexin domains. MMP2 plays a crucial role in tissue remodeling and angiogenesis.
Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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