Thermo Fisher Scientific Bax Polyclonal Antibody
Bax 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 및 랫트에 반응합니다. Western blot, IHC, ICC, IP 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제된 고품질 항체입니다. 세포사멸 연구용으로 권장됩니다.
- 카탈로그번호
- PA585277
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Bax Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Bax |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792420 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Dog (100%), Rhesus Monkey (100%), Bovine (100%).
- Positive Control: 293T, HeLaS3, HepG2, Molt-4, Raji, U2OS.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
BAX is a member of the Bcl-2 family and plays a crucial role in regulating apoptosis. While Bcl-2 is known as an anti-apoptotic protein, BAX functions as a pro-apoptotic factor. Apoptosis regulation involves homo- and heterodimerization of BAX and Bcl-2 isoforms.
The Bax gene encodes isoforms such as Bax alpha (21 kDa) and Bax beta (24 kDa), both containing BH1, BH2, and BH3 domains. Bax beta has a unique C-terminus lacking a hydrophobic transmembrane domain.
BAX overexpression promotes cell death and interacts with other BCL-2 related proteins through dimerization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-85277_BAX_Q07812-1_Rabbit.svg, PA5-85277_BAX_Q07812-1_Rabbit_PDP.jpeg)
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