Thermo Fisher Scientific c-Myc Monoclonal Antibody (9E10), TrueMAB
Thermo Fisher Scientific의 c-Myc Monoclonal Antibody (9E10)은 인간 c-Myc 단백질을 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot, ICC/IF, Flow cytometry, IP 등 다양한 응용에 사용 가능합니다. 고순도 Protein G 정제, 안정적 PBS/BSA/glycerol 저장용액, 연구용으로 최적화된 제품입니다.
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Thermo Fisher Scientific c-Myc Monoclonal Antibody (9E10), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | – |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | – |
| Flow Cytometry (Flow) | Assay-Dependent | – |
| Immunoprecipitation (IP) | Assay-Dependent | – |
| Miscellaneous PubMed (Misc) | – | View 20 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | Synthetic peptide conjugated to KLH, corresponding to C-terminal amino acids 408–432 of human c-Myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.64 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C for up to 3 months; for long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
Synthetic peptide DYKDDDDK conjugated to KLH.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in:
- Cellular proliferation, differentiation, apoptosis, and cell cycle progression
- Phosphorylation at Thr58/Ser62 by GSK3, CDK, ERK2, and JNK, influencing proliferation and cycle regulation
- Vasculogenesis and angiogenesis during tumor development
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini of target proteins.
Amplification of the c-Myc gene has been found in multiple human tumors, including lung, breast, and colon carcinomas. Translocation of the c-Myc locus is associated with Burkitt’s lymphoma and other B-cell proliferative disorders. Aberrant expression of c-Myc occurs in tumors of diverse origins such as colorectal, gastric, hepatic, ovarian, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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