Thermo Fisher Scientific eIF3A/eIF3S10 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Rat, Rabbit, Guinea pig, Orangutan, Monkey, Gorilla, Chimpanzee, and Northern white-cheeked gibbon

Target Information

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773).
The eIF-3 complex associates with the 40S ribosome and facilitates recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5 to form the 43S pre-initiation complex (43S PIC).
It stimulates mRNA recruitment to the 43S PIC and scanning for AUG recognition, and is required for disassembly and recycling of post-termination ribosomal complexes.
The eIF-3 complex specifically targets mRNAs involved in cell proliferation, differentiation, and apoptosis, using different RNA stem-loop binding modes for translational activation or repression (PubMed:25849773, PubMed:27462815).
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: IHC-00589_eIF3a_Q14152-1_Rabbit.svg, IHC-00589_eIF3a_Q14152-1_Rabbit_PDP.jpeg)