Thermo Fisher Scientific STAT4 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–0.5 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with canine and porcine based on sequence homology.

Target Information

STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein shows high similarity to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2, forming homo- and heterodimers with other STAT family members. Tyrosine-phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.

STAT4 expression is mainly found in the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which induces IFN-gamma production and promotes Th1 immune response, essential for defense against intracellular pathogens. STAT4-deficient mice exhibit impaired IL-12-induced Th1 development and enhanced Th2 differentiation. In viral infection, IFN-α/β activation of STAT4 is required for IFN-γ production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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