Thermo Fisher Scientific MAPK7 Monoclonal Antibody (OTI3H2), TrueMAB
MAPK7 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. Western blot, ICC/IF, Flow cytometry에 최적화되어 있으며, 인간 시료에 반응. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3H2 |
| Immunogen | Full length human recombinant protein of human MAPK7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development.
MAPK7 is activated by MAP2K5/MEK5 and participates in downstream signaling of multiple receptors. Upon extracellular stimulation, MAPK7 translocates to the nucleus and regulates gene expression by phosphorylating transcription factors.
Deletion of MAPK7 in mice leads to defective cardiovascular development and embryonic lethality. It plays a critical role in endothelial function and vascular integrity.
ERK5 is expressed in many adult tissues, including heart, placenta, lung, kidney, and skeletal muscle, but not in liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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