Thermo Fisher Scientific WWTR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total TAZ.

Target Information

WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator that functions as a downstream regulatory target in the Hippo signaling pathway, which is crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 with MOB1. MOB1 subsequently phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to the transcriptional machinery such as the mediator complex. It also plays roles in embryonic stem-cell self-renewal, cell proliferation, and epithelial-mesenchymal transition.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.