Thermo Fisher Scientific WWTR1 Polyclonal Antibody
WWTR1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human과 Mouse 시료에서 반응하며, Hippo 신호전달 경로 연구에 활용됩니다. 액상 형태로 제공되며, -20°C에서 보관 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human WWTR1 (Accession Q9GZV5), corresponding to amino acid residues R63–L113 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850298 |
Product Specific Information
Antibody detects endogenous levels of total TAZ.
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator that functions as a downstream regulatory target in the Hippo signaling pathway, which is crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 with MOB1. MOB1 subsequently phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to the transcriptional machinery such as the mediator complex. It also plays roles in embryonic stem-cell self-renewal, cell proliferation, and epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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