Thermo Fisher Scientific Phospho-Bombesin Receptor 3 (Thr370) Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000

Product Specifications

Target Information

BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs, leading to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This “turn-off” activity has tremendous implications for the physiological action of the cell and continues to drive pharmacological research for new drug candidates. Two GPCR-targeted pharmaceuticals, Zyprexa (Eli Lilly) and Claritin (Schering-Plough), have achieved multi-billion dollar market shares in mental health and allergy treatments, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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