Thermo Fisher Scientific Phospho-Arhgap22 (Ser22) Polyclonal Antibody

Thermo Fisher Scientific Phospho-Arhgap22 (Ser22) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Anti-ARHGAP22 pS22 is specific for phosphorylated ARHGAP22 at Serine 22.
• Recognizes S397→A mutation but not S22→A mutation.
• BLAST analysis suggests cross-reactivity with Mouse, Rat, and Human based on 100% sequence homology.
• Cross-reactivity with ARHGAP22 pS22 from other sources has not been determined.

Target Information

GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, downregulating their active form.
ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid cytoplasmic protein containing one Rho-GAP domain and one PH domain.
It functions as a GTPase-activating protein for Rac1, converting it to an inactive GDP-bound state, and interacts with ZNF161 (VEZF1) in transcription regulation.
Multiple isoforms exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.