Thermo Fisher Scientific DIO1 Polyclonal Antibody
Human DIO1 단백질에 특이적인 Rabbit Polyclonal Antibody로 Western Blot에 최적화됨. KLH 접합 합성 펩타이드(30-57 aa)로 면역화. Protein A 및 항원 친화 크로마토그래피로 정제. PBS buffer, 0.09% sodium azide 포함, 4°C 또는 -20°C 보관.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 30–57 amino acids from the N-terminal region of human DIO1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718358 |
Target Information
The protein encoded by this gene is a thiol-requiring, propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) to the bioactive 3,3',5-triiodothyronine (T3) via outer ring deiodination (ORD). It also degrades both hormones by inner ring deiodination (IRD).
Alternative splicing results in multiple transcript variants encoding different isoforms. Some isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes has a stem-loop structure (SECIS) necessary for recognition of UGA as a Sec codon rather than a stop signal.
Additional transcript variants have been described but are not supported by experimental evidence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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