Thermo Fisher Scientific Granzyme B Recombinant Rabbit Monoclonal Antibody (2)

Thermo Fisher Scientific Granzyme B Recombinant Rabbit Monoclonal Antibody (Clone 2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages include:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal-origin-free formulation
• Broader immunoreactivity due to rabbit immune repertoire

This antibody specifically recognizes Human Granzyme B (GZMB).

Target Information

Granzyme B is a serine protease found in the granules of cytotoxic T cells and NK cells. It is also known as CGL1 or CTLA-1, expressed in activated cytotoxic T lymphocytes but not in non-cytotoxic lymphoid cells.

Granzyme B plays a key role in inducing apoptosis in target cells through:

• Interaction with mannose 6-phosphate receptor (death receptor)
• Cleavage of caspase-3 to initiate the caspase cascade
• Activation of mitochondrial apoptosis pathway via Bid protein cleavage

Granzymes (A–G) are neutral serine proteases stored in lytic granules of CTLs and NK cells. In humans, fewer granzymes have been cloned and identified compared to mouse models.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

제품 이미지

(이미지 파일은 본문 하단에 위치)