Thermo Fisher Scientific CD268 (BAFF Receptor) Monoclonal Antibody (eBio7H22-E16), FITC, eBioscience
Mouse BAFF Receptor(CD268)에 특이적인 단클론 항체로, FITC 형광 표지되어 Flow Cytometry에 적합. B세포 활성 및 생존 연구에 활용 가능하며, 0.25 µg/test 농도로 최적화됨. 488 nm/520 nm 형광 특성, Rat IgG1 kappa 아이소타입.
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Thermo Fisher Scientific CD268 (BAFF Receptor) Monoclonal Antibody (eBio7H22-E16), FITC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.25 µg/test | View 9 publications |
| T-Cell Activation (TCA) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio7H22-E16 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_837079 |
Product Specific Information
The monoclonal antibody eBio7H22.E16 reacts with mouse BAFF-Receptor, a type III transmembrane TNF receptor family member. BAFF-R is the predominant BAFF receptor expressed on peripheral B cells in both humans and mice, found on all B220+ B cells in the spleen. It is also expressed on activated/memory T-cell subsets and plays a critical role in splenic B cell maturation, survival, and BAFF-dependent costimulatory responses.
Defects in BAFF-R can cause decreased generation of mature B cells, while overactivation may lead to autoimmune disease. The ligand for BAFF-R is BAFF (BLyS).
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Validated for mouse splenocytes at ≤ 0.25 µg/test (100 µL final volume). Optimal performance should be titrated empirically.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), also known as BAFFR, is encoded by the TNFRSF13C gene (chromosome 22q13.1–q13.31). It is a 184-amino-acid transmembrane protein with 56% identity to the mouse homolog. BAFF enhances B-cell survival and regulates peripheral B-cell populations, playing a key role in B cell development and function through multiple receptors, including BCMA.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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