Thermo Fisher Scientific LCP2/SLP76 Polyclonal Antibody
SLP-76 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. 1 mg/mL 액상 형태로 제공되며, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200 to 250 of human Lymphocyte cytosolic protein 2 (LCP2/SLP76) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat.
The SLP-76 locus has been localized to human chromosome 5q33, and the gene structure has been partially characterized in mice.
The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains:
- N-terminus: Acidic region including a PEST domain and several tyrosine residues phosphorylated following TCR ligation
- Central domain: Proline-rich region
- C-terminus: SH2 domain
SLP-76 associates with multiple proteins constitutively and inducibly after receptor ligation, functioning as an adaptor or scaffold protein.
Studies using SLP-76 deficient T cell lines or mice indicate its positive role in T cell development, activation, and in mast cell and platelet function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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