Thermo Fisher Scientific AKAP12 Polyclonal Antibody
AKAP12 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. IHC(P)와 ICC/IF에 적합하며, 인간 시료에 반응. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AKAP12. Recombinant protein control fragment (Product #RP-103250). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2637805 |
Product Specific Information
Immunogen sequence:
SKDMSEASEK TMTVEVEGST VNDQQLEEVV LPSEEEGGGA GTKSVPEDDG HALLAERIEK SLVEPKEDEK GDDVDDPENQ NSALADTDAS GGLTKESPDT NGPKQKEKED AQEVELQEGK VHSESDKAIT PQAQEELQKQ ERESAKS
Highest antigen sequence identity to the following orthologs:
- Mouse: 30%
- Rat: 34%
Target Information
A-kinase anchor proteins (AKAPs) are structurally diverse proteins that bind to the regulatory subunit of protein kinase A (PKA), confining the holoenzyme to specific cellular locations. The AKAP12 gene encodes a member of this family, expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, functioning as a scaffold protein in signal transduction. AKAP12 and RII PKA colocalize at the cell periphery and are related to cell growth. Antibodies to this protein may be produced by patients with myasthenia gravis. Alternative splicing results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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