Thermo Fisher Scientific SHMT2 Monoclonal Antibody (OTI5H10), TrueMAB
SHMT2 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot에 최적화되어 있습니다. 인간, 마우스, 랫트 반응성을 가지며, Lyophilized 형태로 제공됩니다. 연구용으로 세린-하이드록시메틸트랜스퍼레이스 기능 분석에 적합합니다.
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Thermo Fisher Scientific SHMT2 Monoclonal Antibody (OTI5H10), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5H10 |
| Immunogen | Full length human recombinant protein of human SHMT2 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate.
It exists in two forms: cytoplasmic (SHMT1) and mitochondrial (SHMT2).
cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for SAM synthesis, synthesizes serine, and inhibits SAM synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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