Thermo Fisher Scientific N4BP2L2 Polyclonal Antibody
N4BP2L2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ICC/IF에 적합하며, 인간 및 생쥐 시료 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human N4BP2L2 (Accession Q92802), corresponding to amino acid residues D358–R408 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851183 |
Product Specific Information
Antibody detects endogenous levels of total N4BP2L2.
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that may be involved in transcriptional regulation.
N4BP2L2 is phosphorylated on Ser199 in response to DNA damage, likely by ATM or ATR. It is primarily expressed in bone marrow and is significantly down-regulated after exposure to arsenic compounds, an event preceding neutropenia.
PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the ELA2 gene (encoding Neutrophil Elastase) cause cyclic haematopoiesis, resulting in decreased neutrophil counts and increased susceptibility to infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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