Thermo Fisher Scientific MERS Coronavirus Spike Protein S1 Polyclonal Antibody

Thermo Fisher Scientific MERS Coronavirus Spike Protein S1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Preservative-free formulation.
• Recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
• Specificity: MERS-CoV (NCoV/Novel coronavirus) Spike Protein S1 (aa 1–725).

Target Information

The spike (S) glycoprotein of coronaviruses contains protrusions that bind to specific host cell receptors, playing a crucial role in host specificity and viral infectivity. The term peplomer refers to a group of heterologous proteins on the virus surface that function together.

The S glycoprotein is essential for viral binding and entry into host cells. In SARS-CoV, the spike protein alone can mediate membrane fusion required for virus entry and cell fusion. It serves as a major immunogen and target for entry inhibitors. The S protein consists of two subunits:

• S1 subunit: Contains a receptor-binding domain that interacts with the host cell receptor angiotensin-converting enzyme 2 (ACE2).
• S2 subunit: Mediates fusion between viral and host cell membranes.

The S protein is key in inducing neutralizing-antibody and T-cell responses, contributing to protective immunity during infection.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.