Thermo Fisher Scientific HMGN1 Polyclonal Antibody
Thermo Fisher Scientific의 HMGN1 Polyclonal Antibody는 인간 HMGN1 단백질을 인식하는 토끼 IgG 항체로, Western blot 및 Immunohistochemistry에 적합합니다. 합성 펩타이드 면역원 사용, 액상 형태, 고순도 친화 크로마토그래피 정제 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1.0 µg/mL |
| Immunohistochemistry (IHC) | 5.0 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human HMGN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688618 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 77%; Pig: 86%; Rabbit: 93%; Rat: 100%
Target Information
The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription. HMG-14 and HMG-17 also function as architectural elements that alter chromatin fiber structure and enhance transcription from chromatin templates. These proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of higher-order chromatin structures, facilitating access to DNA sequences. Clustering of architectural elements such as HMG proteins and linker histone subtypes into distinct domains may lead to structural and functional heterogeneity along the chromatin fiber. Additionally, HMG-14 and HMG-17 are constitutive components of mouse oocyte and embryonic chromatin, linking chromatin structure to embryonic development progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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