Thermo Fisher Scientific SCN1A Polyclonal Antibody
SCN1A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, 사람, 마우스, 랫트에 반응합니다. 단백질 A로 정제된 액상 형태로, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human SCN1A (amino acids 1901–2009) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarities, including two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region. ENaC has three homologous isoforms (alpha, beta, gamma) and plays an essential role in sodium and fluid balance in the kidney, lung, and colon. It mediates aldosterone-dependent sodium reabsorption in the distal nephron, thereby regulating blood pressure. Mutations in ENaC subunits are associated with Liddle’s syndrome and pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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